Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free:

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site:, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Google Analytics

Targeted advertising cookies


The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at or by post at:

24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal

Home page

RA3 - Development of infection models

© Inra, Didier Marie
RA3 has as its objectives to provide the project partners with well characterized cell culture systems (primary, finite and established cell lines) as well as stem cells for their specific applications, to intensify the work with vector borne diseases and therefore to optimise the availability of sample material and diagnostic protocols for these diseases and to reinforce the cooperation in fish disease research by generating standardised samples of fish infected with exotic and non-exotic diseases.


The sudden occurrence of Bluetongue disease in central Europe, a disease that was supposed to be restricted to Africa and southern Europe, has taught scientists as well as animal disease officials and politicians several important lessons:

  • the actual spread of any disease or disease agent can never be considered to be stable,
  • it is therefore urgently important for animal as well as human health to carefully watch the development of disease spreads,
  • researchers and diagnosticians should try to establish diagnostic tools for the rapid detection and confirmation of any newly occurring disease,
  • certain animal disease research institutes should produce defined tissue and serum samples from animals infected with the most threatening diseases in order to enable a rapid development and distribution of diagnostic and therapeutic tools, should the respective disease be detected in Europe. Given today’s threats to the present balance of spread between aquatic or terrestrial species and ‘their’ disease agents, mostly represented by the immense travel activities of humans and animals, as well as the movement of endemic zones for both disease vectors and disease agents, this topic is more important than ever before in order to provide a minimum safety of the actual human and animal health situation.


In order to offer optimal tools to diagnosticians as well as researchers for their work, the aim of this workpackage is to produce and present standardized collections of cell culture systems that are essential for the propagation of many disease agents, of reference virus and bacterial strains, and of tissue and body fluid samples from animals naturally or experimentally infected with certain agents. Only if such standardized tools are made available to the research community, a rapid progress in the characterization of so far unknown or hardly known disease agents can be achieved.

Furthermore, an effective collaboration of European institutes working in related fields is only possible if the applied methodology and tools are comparable, if not identical. Cell culture allows knowledge to be gained on cell biology in areas of genetics, proteomics and associated with biological functions involved in physiological and pathological conditions. This knowledge and the efficiency with which cells may be cultured in specialized laboratories will yield tremendous advances in many fields. Biochemical markers can be used to determine define cell types and assay for specialized functions that are relevant for in vivo functions. Morphological features and nucleic acid markers can also be used to characterise the cells.

Task leaders

  • RA3.1 – Cell culture
    Task leader: Friedrich-Loeffler-Institut (Germany)
  • RA3.2 – Vector borne viruses
    Task leader: Centre de Recerca en Sanitat Animal (Spain) and Friedrich-Loeffler-Institut (Germany)
  • RA3.3 – Emerging aquatic animal diseases
    Task Leader: Veterinærinstituttet (Denmark).