Moredun Research Institute (MRI)
Pentlands Science Park
Midlothian, EH26 0PZ
Laboratory involved: Epidemiology and Population Biology and Immunology laboratories.
Sheep immunology and immunogenetics, defining immune mechanisms, immunogenetics of the ovine major histocompatibility complex (MHC), MHC genotyping methods and development of MHC defined antigen presentation systems.
Access contact person
Dr Keith Ballingall
Activities and services
Focus on molecular and cellular immunology in sheep. Virology, bacteriology, parasitology and epidemiology of infectious diseases of sheep.
Description of the access to provide
- Purpose built, large and small animal care, handling and laboratory facilities including Cat 2 and 3 laboratory infrastructures on the Pentlands Science Park Site.
- Linked laboratory facilities specializing in Molecular Biology, Immunology, Parasitology, Bacteriology, Virology and Epidemiology.
- Expertise and support from senior research scientists and support staff with associated bioinformatics, computing and library facilities.
- The unique resource offered by MRI is the MHC-defined research sheep flock with specific application to the analysis of T cell-based immune effector mechanisms, MHC genotyping, immunological analyses and immune reagent development.
- Technical support and consumables up to 2500€ will also be provided per unit of access.
- Number of available access: 4
Number of participants accepted:
Up to two individuals per year, per unit time of 1 month
Travel and subsistence costs
Travel, accommodation and subsistence up to a maximum of 6000€ per unit time.
Conditions of participant involvement
Background knowledge in sheep immunology, sheep infectious disease, immune mechanism or livestock immunogenetics research is required.
After the end of each project the candidate will:
- Submit a short report
- Fill a questionnaire available on-line at: http://cordis.europa.eu/fp7/capacities/questionnaire_en.html
- The participant is entitled to publish the results of its work at the infrastructure in the open literature.All publications resulting from the project should acknowledge this EC-support by mentioning : “The research leading to these results has received funding from the European Community‘s Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 228394”
- Proprietary research (research where results are not generally available to the public or only made available under confidentiality arrangements) cannot be supported.
- Travel and subsistence expenses linked to the access will be reimbursed upon approval of the report. Reimbursements will be done according to administrative rules of each hosting organisation.
- For more information about transnational access conditions, see the ANNEX III to the Grant Agreement - Infrastructures
Infrastructure ethical rules
All experimentation involving animals has to be covered by UK government home office regulations including project and personal licences and individual experiments have to be evaluated and approved by the MRI Experiments and Ethics Committee.
- Ovine trophoblast is a primary source of TNFalpha during Chlamydophila abortus infection. Wheelhouse N, Wattegedera S, Stanton J, Maley S, Watson D, Jepson C, Deane D, Buxton D, Longbottom D, Baszler T, Entrican G. J Reprod Immunol. 2009, 80:49-56.
- Genomic organisation and allelic diversity within coding and non-coding regions of the Ovar-DRB1 locus. Ballingall, KT, Fardoe, K, McKeever, DJ. Immunogenetics, 2008, 60:95-103.
- Genetic and proteomic analysis of the MHC class I repertoire from four ovine haplotypes. Ballingall, KT, Miltiadou, D, Chai, ZW, Mclean, K, Rocchi, M, Yaga, R, McKeever, DJ. Immunogenetics 2008, 60:177-184.
- A current perspective on availability of tools, resources and networks for veterinary immunology. Entrican G, Lunney JK, Rutten VP, Baldwin CL. Vet Immunol Immunopathol. 2009, 128:24-29.
- Infrastructure website: http://www.moredun.org.uk/